Galileo Tissue Microarrayer
TMA Technology is a technical procedure that combines tens to hundreds of paraffin-embedded tissue specimens into a single paraffin block. Cylindrical tissue cores (typically 0.6-2.0mm in diameter) are acquired from one or more representative regions of a paraffin-embedded tissue block (donor block) and then precisely arrayed into a new “recipient” paraffin block, using a customer-built instrument. Up to 200 consecutive sections of 4.5µm thickness can be cut from each TMA block, mounted on a microscope slide and processed like ordinary tissue sections with a wide range of techniques (histochemical staining, immunohistochemical and immunofluorescent staining, FISH).
Cell Micro Array Technology evolved from TMA with the exception that cells are pelletted. Cells grown in culture are fixed, suspended in Agarose and embedded in paraffin.
Galileo can be used for TMA, CMA and as a sample picker for nucleic acids (DNA and RNA) extraction and for protein isolation using appropriate fixative. The tissue cores extracted from precise regions of interest may be dispensed into dedicated vessels for further processing such as DNA, RNA, miRNA and protein extraction. Microfuge vials, strips or microtiter plates may be used, depending on the downstream applications. Parallel analyses on the same specimen can be performed simultaneously.
Cell Micro Array Technology evolved from TMA with the exception that cells are pelletted. Cells grown in culture are fixed, suspended in Agarose and embedded in paraffin.
Galileo can be used for TMA, CMA and as a sample picker for nucleic acids (DNA and RNA) extraction and for protein isolation using appropriate fixative. The tissue cores extracted from precise regions of interest may be dispensed into dedicated vessels for further processing such as DNA, RNA, miRNA and protein extraction. Microfuge vials, strips or microtiter plates may be used, depending on the downstream applications. Parallel analyses on the same specimen can be performed simultaneously.
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